In recent years attention has been drawn to multipotential cells such as periosteal cells and mesenchymal progenitors form bone marrow, aspirates and subchondral bone. These cells have the ability to migrate, to undergo extensive replication, and to develop into mesenchymal tissue such as bone and cartilage. These progenitors are therefore attractive cells for regenerative medicine approaches.
The procedures for isolation, expansion and preservation as well as the phenotypic and functional characterization and investigation of the in vitro differentiation of these multipotent cells are established. Also well known are applications of these cells, e.g. cell transplantation. Our cell-based therapies are indicated in articular cartilage lesions and defects and in jawbone defects.